London e-Science Centre homepage London e-Science Centre homepage UK Research Council - e-Science homepage
 
Home Page
Projects
  Sun CoE in e-Science
  Sun Grid Engine Intergration
  Intel Virtual Grid Centre
  GridSAM
  EPIC
  Multi-User Multi-Job Utilisation
  OSCAR-G
  Community Authorisation Server
  Computational Markets
  OGSA Evaluation
  WoSE
  CoreGRID
  RealityGrid
  Discovery Net
  GENIE
  Proteome Grid
  Microarray Analysis
  BAIR
  GridCC
  GridPP
  APPP
  inSORS Collaboration
  MESSAGE
  CLAHRC
  TRANSFORM
Supported Activities
Resources
Services
News and Events
Publications
ICENI- Grid Middleware
Articles and Links
Current Vacancies
Contacts

[E_MAASlogo.jpg]

Extensible MicroArray Analysis System

Overview

This BBSRC supported e-Science project aims to develop a distributed e-Support system for microarray data analysis and management across several campuses at Imperial College. The principal objectives are: To extend the facilities and expertise in the Imperial College Bioinformatics Support Service; The analysis of functional genomics data and its integration with data management and analysis tools, using Grid-enabled technologies.

Work Packages

The proposed system is divided into three components and their associated work packages.

  • e-Science Related Tasks
    • Portal infrastructure
    • Distributed training and support
    • Integration of remote resources
  • Bioinformatics and support related tasks
    • Design of an administrative interface
    • Development of user interface including integration of selected microarray software
    • Evaluation of an e-support portal system in a working environment from both a research and a support perspective
    • Downstream Evaluation and Development
  • Data Management Tasks
    • Design of new interface for the MiMir data warehouse
    • Integration of new locally developed software and methodologies
    • Design and Implementation of structures for holding the intermediate stages of analysis
    • History-tracking for analysis stages

The proposed infrastructure will support:

  • Data transfer between specialised sites and data repositories
  • Access to online expertise for researchers in data analysis and management from the Bioinformatics Support Service and Microarray Centre
  • Fast-track access for biological researchers to new models and algorithms developed in house and externally e.g. statisticians
  • Single point access to a range of multi-platform tools and packages for microarray analysis with seamless data flow via a range of data reformatting tools
  • Fully automatic tracking of any analyses performed
  • A functional system sufficiently robust and simple to use that it can be readily implemented and used by researchers

Current Status

We are currently working towards a demonstrable prototype e-support system showing integration of several key features. For the user interface we are using open source portal software Gridsphere and uPortal. For an initial exemplar microarray data analysis package, we are using the open-source statistical package R together with Bioconductor. We are looking into importing and exporting MAGE-ML formatted data through the MiMiR data warehouse (see http://microarray.csc.mrc.ac.uk//subsection.html?id=28).

Partners:

This project is a collaboration between the Centre for Bioinformatics, Faculty of Life Sciences (Butcher, Sternberg), LeSC (Darlington, Jevons, Saleem) and the CSC/IC Microarray Centre (Aitman, Game).


Back to top

Comments to lesc@imperial.ac.uk. © The London e-Science Centre.
This page was last modified on Thu Apr 15 13:12:48 BST 2010