Welcome to the London e-Science Centre at Imperial College London. The Centre has been established as part of the EPSRCs Core Technology programme in the national e-Science initiative. The London e-Science Centre is the natural successor to the Imperial College Fujitsu Parallel Computing Centre and the Imperial College Parallel Computing Centre, which, in their various ways, have promoted the use of parallel and high-performance computing in a wide variety of application areas. We very much look forward to continuing these endeavours as part of the challenging and exciting e-Science programme. Professor John Darlington Director London e-Science Centre